Adipose-Specific GHR Knockout Confers Multidimensional Anti-Aging Advantages via Adipose Tissue Remodelling and Enhanced Metabolic Elasticity.

Rui Ma, Liyuan Ran, Jinyang Geng, Yue Zhang, Jie Liu, Zichao Yu, Bin Liang, Li Qiang, Yingjie Wu

Institute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, China. · pubmed

Paper

Abstract

Global growth hormone receptor knockout (GHR

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that adipose-specific GHR knockout leads to anti-aging benefits through tissue remodeling and improved metabolic flexibility. This research addresses mechanisms that could potentially mitigate aging processes rather than merely treating age-related diseases.

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