Metabolic, epigenetic, and immune crosstalk in ovarian aging.

Jing Li, Qianhui Liao, Yan Yang, Kang Wang, Weiai Liu, Fang Zhou, Huiping Liu, Ye Zhang

School of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China.School of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China. · pubmed

Paper

Abstract

Ovarian aging, marked by follicle depletion and oocyte quality decline, involves complex metabolic alterations. This review synthesizes evidence that dysregulated metabolic reprogramming, encompassing energy, lipid, and nutrient metabolism, drives ovarian functional decline. Central to this process is a self-reinforcing "metabolism-epigenetics-immunity" triangular network, where mitochondrial dysfunction and NAD

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Research summary

Dysregulated metabolic reprogramming drives ovarian functional decline through a metabolism-epigenetics-immunity network. This paper addresses the underlying metabolic and epigenetic mechanisms of ovarian aging, which are crucial for understanding the biological processes of aging and potential interventions for lifespan extension.

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