Do metabolic fluxes change with age?

Sebastian J Hofer, Anna Katharina Simon, Frank Madeo

Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany. Electronic address: [email protected]ück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany. Electronic address: [email protected]. · pubmed

Paper

Abstract

Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.

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Research summary

The paper discusses the relationship between age and metabolic fluxes, suggesting that understanding these changes could recalibrate our understanding of aging metabolism. This research is relevant as it addresses fundamental aspects of aging metabolism, which could contribute to insights into the root causes of aging.

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