Paeonol alleviates granulosa cell senescence in laying chickens via the PI3K/Akt/mTOR signaling pathway.

Yingyu Xiao, Qiongyu Yuan, Xiangyu Cai, Zhaoyu Yang, Wanyue Gao, Jing Dong, Weidong Zeng, Caiqiao Zhang, Yuling Mi

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. · pubmed

Abstract

Ovarian aging compromises reproductive health and reduces egg production, posing a persistent challenge to the poultry industry. Mitochondrial dysfunction in granulosa cells (GCs) accelerates reactive oxygen species (ROS) accumulation and induces apoptosis in both GCs and oocytes. The impact of Paeonol on mitochondrial function in avian GCs remains unclear.

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Research summary

Paeonol alleviates granulosa cell senescence in laying chickens by targeting the PI3K/Akt/mTOR signaling pathway. This research addresses a specific aspect of cellular aging in granulosa cells, which is relevant to understanding and potentially mitigating age-related reproductive decline.

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