Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis.

Wuping Liu, Zhaoyu Yang, Changhan Chen, Fang Yu, Mengzhi Wu, Zhouzhou Yao, Yuhua Fan, Tingting Xie, Linlin Wan, Tiansheng Chou, Xianjing Feng, Hao Qi, Yuyu Chou, Juan Zhao, Juan Liu, Zhiyu Yang, Yujin Zhang, Rodney E Kellems, Yang Xia

National Medical Metabolomics International Collaborative Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China. · pubmed

Paper

Abstract

Aging-related diseases are aggravated by tissue hypoxia; however, the underlying mechanism remains unknown. Here, we report that the oxygen (O

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Research summary

Inosine promotes erythrocyte metabolic reprogramming to enhance oxygen release via the 2,3-BPG-PNP axis. The study addresses a mechanism related to tissue hypoxia, which is a significant factor in aging-related diseases, suggesting a potential pathway for rejuvenation and longevity.

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