Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin-IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial.

Moritz V Warmbrunn, Lin Yang, Raaj Kishore Biswas, Calen P Ryan, Andrew Harper, Daniel W Belsky, Giovanni Fiorito, Luigi Fontana

Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. · pubmed

Paper

Abstract

To investigate the long-term metabolic and hormonal consequences of sustained weight loss versus weight regain after 1 year of caloric restriction (CR), with attention to insulin resistance and type 2 diabetes risk.

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Research summary

Weight regain after caloric restriction reverses benefits on the insulin-IGF-1 nutrient-sensing pathway. This study is relevant as it explores the metabolic consequences of weight management, which is crucial for understanding mechanisms that influence aging and age-related diseases like type 2 diabetes.

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