Linoleic Acid Supplementation Attenuates Inflammation and Redox Imbalance During Aging in Wistar Rats.

Parisha Srivastava, Avnish Kumar Verma, Akanksha Singh, Raushan Kumar, Syed Ibrahim Rizvi

Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh 211002 India.Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh 211002 India. · pubmed

Paper

Abstract

Aging is the result of the accumulation of a variety of cellular and molecular damage over time. The oxidative stress-induced functional impairments are known to be the cause of age-related deficits. This study aimed to evaluate the effect of Linoleic acid (LA) supplementation on biomarkers of oxidative stress and inflammation in blood of young and old rats. Male rats in young and old groups were divided randomly into four distinct groups (n = 6). Group I: Young Control, Group II: Young Treated, Group III: Old Control, Group IV: Old Treated. Group II and IV were administered with LA (5 mg/kg body weight) orally via gavage for 28 days. After completion of the experimental protocol, rats were sacrificed and parameters of oxidative stress and inflammation were determined. Results show a significant (

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Research summary

Linoleic acid supplementation reduces inflammation and oxidative stress in aging rats. The study addresses the impact of a dietary intervention on biomarkers associated with aging, which is relevant to understanding potential strategies for mitigating age-related decline.

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