Glomerular hyperfiltration and enhanced sensitivity to kidney ischemia reperfusion with a blunted KIM-1 response in young male aging-accelerated SAMP8 mice.

Helen A Goodluck, Sadhana Kanoo, Young Chul Kim, Natalia Lopez, Yuji Oe, Antonio Jose Martins Currais, Pamela Maher, Volker Vallon

Dept. of Medicine, Univ. of California San Diego, and VA San Diego Healthcare System, San Diego, CA, USA. · pubmed

Paper

Abstract

To better understand the impact of accelerated aging on kidney function, we compared standard C57BL6 mice (C57BL6) with Senescence Accelerated Mouse-Prone 8 mice (SAMP8). Young male SAMP8 (3&6 months) showed glomerular hyperfiltration compared with C57BL6 (absolute and per body weight), followed by gradual GFR decline, lower blood pressure, and enhanced mortality over the first 15 months of life. This was associated with higher kidney, heart and liver but not brain weights. Female SAMP8 likewise showed a faster early rise in body weight, higher organ weights, and a somewhat higher mortality, but GFR and blood pressure appeared unaltered vs. C57BL6. Since GFR phenotype was stronger in male mice, they were subjected to bilateral renal artery clamping-induced kidney ischemia-reperfusion (IR). One day after IR, young SAMP8 (3 months) showed higher plasma creatinine and kidney VCAM1 expression and subsequent mortality but a blunted rise in kidney

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Research summary

The paper claims that young male SAMP8 mice exhibit glomerular hyperfiltration and increased sensitivity to kidney ischemia-reperfusion injury, highlighting the effects of accelerated aging on kidney function. This research is relevant as it explores the mechanisms of aging and their impact on organ function, contributing to the understanding of age-related diseases.

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