Betulinic Acid Attenuates Vascular Smooth Muscle Cell Senescence and Aortic Vascular Aging via PPAR-α/CPT1A-Mediated Fatty Acid Oxidation.

Tingting Lu, Linghuan Wang, Sijia Chen, Tianhu Wang, Naiyuan Sun, Cheng Qin, Jin Yan, Yan Ma, Huijia Yin, Xiaoying Shen, Feng Cao

School of Medicine, Nankai University, Tianjin, China. · pubmed

Paper

Abstract

Vascular stiffness and aging are critical contributors to cardiovascular diseases. Whether betulinic acid (BA), a natural triterpenoid, alleviates vascular aging remains unclear. Mouse aortic smooth muscle cells (MASMCs) with oleic acid (OA)-induced lipotoxic senescence were treated with BA (30 μM). Transcriptomic analysis and functional assays were conducted.

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Research summary

Betulinic acid attenuates vascular smooth muscle cell senescence and aortic vascular aging through PPAR-α/CPT1A-mediated fatty acid oxidation. The study addresses mechanisms of vascular aging, which are fundamental to understanding and potentially mitigating age-related cardiovascular diseases.

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