Testicular SIRT1 Loss Reveals an Aging-Like Proteomic Landscape and Precipitates Reproductive Deterioration.

María Iniesta-Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic. · pubmed

Paper

Abstract

Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD

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Research summary

Loss of SIRT1 in testicular tissue leads to an aging-like proteomic profile and reproductive decline. This study addresses the molecular mechanisms underlying aging and their impact on fertility, which is pertinent to understanding the biological processes of aging.

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