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RESEARCH PAPER / 2026-03-13

Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.

Yicheng Ma, Junming Han, Qihang Li, Xiao Jiang, Yuan Li, Keke Zhang, Ling Gao

Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. · pubmed

Abstract

The age-specific magnitude of the impact of hormones on aging and the role of hormone replacement therapy (HRT) remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that the timing of hormone replacement therapy (HRT) can influence biological aging in females. This research is relevant as it explores the role of hormones in the aging process, potentially addressing a root cause of aging rather than merely treating symptoms.

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