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RESEARCH PAPER / 2026-03-12

Biological age acceleration in primary aldosteronism: associations with renin, aldosterone, aldosterone-to-renin ratio, and left ventricular mass index.

Ning Li, Ningpeng Liang, Xiangtao Zhang, Yifei Dong

Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University. · pubmed

Abstract

To investigate the associations of plasma aldosterone concentration (PAC), plasma renin activity (PRA), and aldosterone-to-renin ratio (ARR) with Gompertz law-based biological age difference (GOLD BioAgeDiff) in patients with primary aldosteronism versus essential hypertension (EHT), and to determine whether GOLD BioAgeDiff relates to cardiac mass.

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Research summary

The paper investigates the associations between biological age acceleration and various biomarkers in primary aldosteronism. This research is relevant as it explores biological age differences, which can provide insights into the mechanisms of aging and potential interventions for age-related diseases.

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