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RESEARCH PAPER / 2026-03-12

Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial.

Alexandra Papaioannou, Courtney Kennedy, Justin Lee, Patricia Hewston, Caitlin McArthur, Shyam Maharaj, Jonathan Adachi, Pauline Boulos, Raja Bobba, Alexander Rabinovich, Brian McKenna, Lisa Palubiski, Dee Mangin, Lehana Thabane, Sharon Marr, Sharon Kaasalainen, Jean-Éric Tarride, Olga Theou, David Armstrong, Ahmed Negm, Michael Noseworthy, Kenneth Rockwood, Lisa Dolovich, Hajar Abu Alrob, Genevieve Hladysh, Karen Thompson, George Ioannidis

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, McMaster University, Hamilton, Ontario, Canada. · pubmed

Abstract

Frailty in older adults is on the rise with the rapid aging population. Frailty is dynamic and proven to be reversible or treatable. Evidence regarding the clinical effectiveness of community-based frailty interventions is limited. Frailty rehabilitation has the potential to be an accessible community-based intervention that may enable independence. We will examine a model of frailty rehabilitation and consider key components for improving physical function, frailty, sarcopenia, and cost-effectiveness.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that community-based frailty rehabilitation can improve physical function in older adults. This research is relevant as it addresses frailty, a significant aspect of aging that can impact longevity and independence in older populations.

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