Intestinal interoceptive dysfunction drives age-associated cognitive decline.

Timothy O Cox, Ashwarya S Devason, Alan de Araujo, Sydney Mason, Madhav Subramanian, Andrea F M Salvador, Hélène C Descamps, Junwon Kim, Yixuan Zhu, Lev Litichevskiy, Sunhee Jung, Won-Suk Song, Adrián Cortés-Martín, Nathan T Henderson, Kuei-Pin Huang, Thao Nguyen, Wisath Sae-Lee, Iboro C Umana, Maria Sacta, Ryan J Rahman, Stephen Wisser, J Andrew D Nelson, Ilona Golynker, Alana M McSween, Eric F Hohmann, Shaan Patel, Anna L Bub, Clara Soekler, Niklas Blank, Kevt'her Hoxha, Lavinia Boccia, Andrea C Wong, Klaas Bahnsen, Jihee Kim, Natalie Biderman, Dina Abbasian, Clarissa Shoffler, Christopher Petucci, Fiona E McAllister, Amber L Alhadeff, Marc V Fuccillo, Colin Hill, Cholsoon Jang, J Nicholas Betley, Guillaume de Lartigue, Virginia Y-M Lee, Maayan Levy, Christoph A Thaiss

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. · pubmed

Paper

Abstract

Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population

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Research summary

Intestinal interoceptive dysfunction contributes to cognitive decline associated with aging. This paper addresses a potential root cause of cognitive decline in aging, which is relevant to understanding and potentially mitigating age-related cognitive deterioration.

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