Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome.

Menglong Feng, Xiaoqing Zhou, Ting Yang, Zhiji Chen, Guijun Yang, Xu Jiang, Wei Yuan

Department of Otolaryngology & Head and Neck, Chongqing General Hospital, Chongqing University, Chongqing, China. · pubmed

Paper

Abstract

Age-related hearing loss (ARHL), the most prevalent sensory impairment in older adults, is closely associated with NOD-like receptor thermal protein domain-containing protein 3 (NLRP3) inflammasome activation and mitochondrial dysfunction. Quercetin, a natural flavonoid, shows anti-inflammatory and antioxidant properties, but its role in ARHL remains unclear. In this study, we investigated the protective effects and underlying mechanisms of quercetin on ARHL in a mouse model, focusing on both NLRP3 inflammasome and mitophagy.

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Research summary

Quercetin prevents age-related hearing loss by activating mitophagy and inhibiting the NLRP3 inflammasome. This study addresses mechanisms related to aging and age-related diseases, specifically targeting mitochondrial dysfunction and inflammation, which are considered root causes of aging.

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