Independent and combined associations of maternal one-carbon nutrition biomarkers and dietary patterns with epigenetic age acceleration: Evidence from the Boston Birth Cohort.

Nusrat Jabin, Guoying Wang, Xiumei Hong, Serena Rusk, Tina L Cheng, Xiaobin Wang

Center On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.Center On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA. · pubmed

Paper

Abstract

Pregnancy functions as a "stress test" with implications for women's long-term health. We hypothesize that maternal biological aging, measured by epigenetic age acceleration (EAA), can be influenced by one-carbon nutritional status (folate, vitamin B₁₂, homocysteine), adherence to the Mediterranean diet, and prenatal multivitamin use. We analyzed data from 742 mothers enrolled in the Boston Birth Cohort (1998-2013). EAA was defined as the difference between the Levine epigenetic clock-DNA methylation-based measure and chronological age at delivery. Mediterranean-diet adherence and prenatal multivitamin use were assessed using a validated food frequency questionnaire administered within 24-72 h postpartum. Blood DNA and plasma samples used to measure folate, B

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Research summary

Maternal one-carbon nutritional status and dietary patterns are associated with epigenetic age acceleration in mothers. This study explores factors that may influence biological aging during pregnancy, which is pertinent to understanding longevity and the root causes of aging.

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