Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank.

Chi-Shin Wu, Mei-Chen Lin, Chi-Fung Cheng, Shu-Fen Liao, Mei-Hsin Su, Yi-Jiun Pan, Shi-Heng Wang

National Center for Geriatrics and Welfare Research, National Health Research Institutes, Zhunan, Yunlin, Taiwan.National Center for Geriatrics and Welfare Research, National Health Research Institutes, Zhunan, Yunlin, Taiwan. · pubmed

Paper

Abstract

Sleep traits have been linked to cognitive aging, but observational associations are susceptible to confounding and reverse causation. Using genetically informed polygenic risk scores (PRSs), this study examined associations between genetic liability to sleep traits and cognitive function in an East Asian population. We further assessed whether educational attainment, as a marker of cognitive reserve, modifies these associations.

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Research summary

The paper claims that genetic liability to sleep traits is associated with cognitive function in older adults, with educational attainment modifying these associations. This research is relevant as it explores the genetic underpinnings of sleep and cognitive function, which are critical factors in the aging process and longevity.

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