Superenhancer-mediated ferroptosis in age-related hearing loss: cochlear epigenomics.

Chanyuan Zhang, Ting Yang, Xiaoqin Luo, Xiaolong Fu, Yan Sun, Wei Yuan

Qingdao Medical College, Qingdao University, Qingdao, China.Qingdao Medical College, Qingdao University, Qingdao, China. · pubmed

Paper

Abstract

Age-related hearing loss (ARHL), also known as presbycusis, is a prevalent condition among older adults and affects a substantial proportion of the global aging population. The underlying mechanisms of ARHL remain unclear, and this study aimed to explore the role of superenhancers (SEs) and the transcription factor Sp1 in regulating hair cell (HC) aging and ferroptosis, a form of regulated cell death associated with iron metabolism.

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Research summary

The paper claims that superenhancers and the transcription factor Sp1 regulate hair cell aging and ferroptosis in age-related hearing loss. This research addresses mechanisms underlying a specific age-related condition, contributing to the understanding of aging processes.

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