Dietary restriction in aging and longevity.

Tomas Schmauck-Medina, Sofie Lautrup, Andrea Di Francesco, Sarah J Mitchell, Christoffer Clemmensen, Linda Partridge, George S Roth, Rozalyn M Anderson, Julie A Mattison, Rafael de Cabo, John R Speakman, Arlan Richardson, Donald K Ingram, Richard Weindruch, Mark P Mattson, Evandro F Fang

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. · pubmed

Paper

Abstract

Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular levels proliferated. Here we review the evidence testing a variety of DR paradigms in the context of aging, focusing on mammalian findings. We discuss potential DR mimetics that modulate autophagy, FGF21, AMPK, mTORC1, NAD

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Research summary

The paper reviews various dietary restriction paradigms and their effects on aging and longevity. The focus on dietary restriction as a means to influence aging processes aligns with the goal of understanding and potentially mitigating the root causes of aging.

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