Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study.

Sung Hye Kong, Ok Hee Jeon, Ji Yeon Kim, Miji Kim, Jinhee Kim, Seung Shin Park, Hak Chul Chang, Chang Won Won, Dohyun Han

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. · pubmed

Paper

Abstract

Sarcopenia is an age-related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.

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Research summary

The paper identifies distinct proteomic signatures associated with the progression of sarcopenia. This research is relevant as it explores molecular biomarkers that could potentially address the underlying mechanisms of age-related muscle decline, contributing to the broader understanding of aging and longevity.

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