Volatilomics insights in older adults with diabetes: from metabolic mechanisms to precision geriatric medicine.

Manuela Giovanna Basilicata, Lucia Scisciola, Ada Pesapane, Rosaria Anna Fontanella, Nunzia Balzano, Alberta Maria Maddalena Palazzo, Rashmi Joshi, Asad Zia, Giovanni Tortorella, Zeeshan Ulfat, Maryam Arshad, Giovanna Aquino, Eduardo Sommella, Marco Malavolta, Angelica Giuliani, Pietro Campiglia, Michelangela Barbieri, Giuseppe Paolisso

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy. · pubmed

Paper

Abstract

This review aims to evaluate the hypothesis that Volatilomics-the comprehensive analysis of volatile organic compounds (VOCs) from breath, skin, urine, and other biological matrices-can serve as a non-invasive tool to characterize metabolic alterations associated with aging and diabetes mellitus in older adults, supporting precision geriatric medicine.

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Research summary

Volatilomics can be utilized to identify metabolic alterations in older adults with diabetes, potentially aiding in precision geriatric medicine. The paper addresses metabolic mechanisms associated with aging and diabetes, which are critical for understanding age-related diseases and improving longevity outcomes.

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