Dynamics of gut bacteriophage in diversity outbred mice studied over lifespan and during extreme caloric restriction.
Abstract
The majority of bacteria in the vertebrate gut harbor integrated bacterial viruses ("bacteriophages" or "phages"; integrated phage are termed "prophages"). To probe phage replication strategies in the mammalian gut microbiome, we investigated phage activity in a large longitudinal study of diversity outbred mice (913 animals) undergoing extreme dietary restriction with detailed phenotypic characterization across lifespan.
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Research summary
The paper investigates the dynamics of gut bacteriophage activity in relation to extreme caloric restriction in mice over their lifespan. This research is relevant as it explores the interactions between gut microbiome components and dietary interventions, which may have implications for understanding aging and lifespan extension mechanisms.
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