ReFIT study (reversing frailty in transplantation): protocol for a longitudinal study to assess clinical and biomedical changes in frailty through kidney transplantation.

Trent Payne, Alyra Shaw, Leila Shafiee Hanjani, Ryan Homes, Fiona Giddens, Halley Gora Ravuri, Chloe X Yap, James Walsh, Vinod Kumar, Fleur C Garton, Handoo Rhee, Alan Huang, Ross S Francis, Natasha Reid, Mara McAdams-DeMarco, Emily Gordon, Mark Midwinter, Ruth Hubbard

Australian Frailty Network, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia [email protected] Frailty Network, Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia [email protected]. · pubmed

Paper

Abstract

Losses of functional reserve across multiple physiological systems have been identified in frail patients, yet the exact aetiology of frailty remains unclear. Although strongly associated with chronological age, frailty often develops at a younger age in patients with organ failure. Frailty is prevalent in patients with kidney failure; however, individuals experience improvements in physical frailty measures following kidney transplantation. This makes younger patients with kidney failure a unique population for studying both the accelerated onset of frailty and its reversal. This research project aims to test the hypothesis that frailty secondary to organ failure and age-related frailty are associated with similar molecular and physiological measures.

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Research summary

The study aims to investigate the association between frailty due to organ failure and age-related frailty through kidney transplantation. This research is relevant as it explores the underlying mechanisms of frailty, which is a significant aspect of aging and longevity.

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