Bioactive peptide matrikines: discovery approaches for skin rejuvenation.

Tess Birtles, Zeyad El-Houni, Krishan Mistry, Matiss Ozols, Eleanor J Bradley, Mike Bell, Joe Swift, Michael J Sherratt, Alexander Eckersley

Divisions of Musculoskeletal & Dermatological Sciences, The University of Manchester, Manchester, UK.Divisions of Musculoskeletal & Dermatological Sciences, The University of Manchester, Manchester, UK. · pubmed

Paper

Abstract

Ageing of human skin is driven in part by cumulative damage to extracellular matrix (ECM) proteins, resulting in wrinkles, laxity, and reduced capacity to heal. Bioactive peptide matrikines are promising therapeutic agents capable of stimulating ECM regeneration and remodelling. This review focuses on how the discovery strategies to identify these peptides have evolved over several decades of cosmeceutical use. Early peptide matrikines were identified primarily through repetitive

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Research summary

The paper discusses the potential of bioactive peptide matrikines to stimulate extracellular matrix regeneration and remodeling for skin rejuvenation. This research is relevant as it addresses mechanisms that could contribute to the aging process of skin, which is a significant aspect of overall longevity and age-related changes.

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