Erzhi pills: a potential aging-modulating agent targeting immunosenescence in mice.

Zhirui Fang, Wei Sun, Na Li, Tingting Shi, Xiuyun Ren, Rui Zhang, Yujing Zhang, Jing Chen, Qi Liu, Meng Wang, Lu Chen, Hong Wang

Instrumental Analysis and Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.Instrumental Analysis and Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. · pubmed

Paper

Abstract

Erzhi Pills (EZP), a traditional Chinese herbal formula, has demonstrated potential aging-modulating properties, while its mechanisms in modulating immunosenescence remain incompletely understood. Two complementary aging murine models were employed to investigate the anti-immunosenescence efficacy of EZP, providing experimental validation for its translational application in delaying age-related immune decline. Morphological and physiological parameters were monitored and thymic/splenic organ coefficients were calculated. Histopathological evaluation of thymic involution was performed via hematoxylin-eosin (H&E) staining. Flow cytometry quantified splenic T cell subsets (naïve/memory CD4

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Research summary

Erzhi Pills may modulate immunosenescence in aging mice. The study investigates a potential intervention targeting the aging process by addressing immune decline, which is a significant aspect of aging.

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