Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.

Jingyu Chen, Meng Xue, Shuyi Mi, Anbo Fu, Wenwen Chen, Yuhao Sun, Shenglong Xia, Qiwei Ge, Jiakai Luo, Qiao Yu, Liangjing Wang, Shujie Chen

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. · pubmed

Paper

Abstract

Intestinal aging characterized by imbalance between cell senescence and mucosal self-renewal, increases susceptibility to the elderly-onset ulcerative colitis (UC), while the underlying mechanisms remain elusive. Here, we identify mRNA N4-acetylcytidine (ac

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Research summary

Targeting NAT10 can alleviate colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A. This research addresses the mechanisms underlying intestinal aging and its impact on age-related diseases, contributing to the understanding of aging processes.

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