Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation.

Qi Xue, Yueqiang Gu, Ran Qin, Zijia Chen, Jie Li, Mingying Li, Yiping Li, Changhao Li, Weicheng Gao, Baohua Liu, Renlei Yang

Department of Plastic Surgery, Affiliated Friendship Plastic Surgery Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. · pubmed

Paper

Abstract

Age-related knee osteoarthritis (OA) arises from cumulative oxidative damage, chondrocyte senescence and extracellular matrix loss; yet safe and effective disease‑modifying interventions for aging‑associated OA are lacking. Pyrroloquinoline quinone (PQQ; molecular formula C

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Research summary

Pyrroloquinoline quinone (PQQ) alleviates age-related osteoarthritis through a specific stress response mechanism. The paper addresses a potential intervention targeting the underlying mechanisms of age-related osteoarthritis, which is relevant to longevity research.

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