Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort.

Jiatong Shan, Jian Hua Tay, Kaisy Xinhong Ye, Jiuyu Guo, Luwen Cao, Yan Zeng, Tih-Shih Lee, Kua Ee Heok, Brian K Kennedy, Andrea B Maier, Lei Feng

Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore; Centre for Healthy Longevity, National University Health System, Singapore 117456, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119007, Singapore. · pubmed

Paper

Abstract

Lifestyle factors play a critical role in healthy aging, yet their relationships with aging biomarkers remain insufficiently characterized, particularly in Asian populations. This study aimed to examine the cross-sectional and longitudinal associations between 15 modifiable lifestyle factors and two DNA methylation (DNAm) clocks (GrimAge acceleration [AgeDev] and DunedinPACE) in a cohort of older Asian adults.

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Research summary

The paper claims that modifiable lifestyle factors are associated with DNA methylation-based aging clocks in older Asian adults. This research is relevant as it explores the relationship between lifestyle choices and biological aging markers, contributing to the understanding of healthy aging and potential interventions for longevity.

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