Unlocking ovarian rejuvenation with platelet-rich plasma: systematic review and proposed clinical framework for Controlled use in poor prognosis patients undergoing in vitro fertilisation.

Arwa A Alageel

Clinical Laboratories Science, College of Applied Medical Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia. [email protected] Laboratories Science, College of Applied Medical Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia. [email protected]. · pubmed

Paper

Abstract

Platelet-rich plasma (PRP) is used as an adjunctive treatment in various medical fields, including orthopaedics, plastic surgery, dermatology, and wound healing. However, PRP application in reproductive medicine, particularly for fertility restoration, remains controversial, specifically for women with diminished ovarian reserve (DOR), premature ovarian insufficiency (POI), and pre-menopause. This systematic review aimed to comprehensively evaluate the existing literature on autologous PRP use for ovarian rejuvenation, with a focus on refining and standardising PRP protocols and identifying appropriate candidate populations.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper proposes a clinical framework for using platelet-rich plasma to rejuvenate ovarian function in women with diminished ovarian reserve. This research is relevant as it addresses potential interventions that could improve reproductive health and longevity by targeting ovarian function, which is a critical aspect of female aging.

Author of this paper? Send a correction.