Protective Effect of Exercise Training Against Age-induced Cerebral Microvascular Rarefaction: VEGF/Flk-1/PI3K/Akt Signaling and GLUT1 Expression.

Sheepsumon Viboolvorakul, Decha Buranajitpirom, Suthiluk Patumraj

Physiology Unit, Department of Medical Science, Faculty of Science, Rangsit University, Pathum Thani, Thailand; [email protected] Unit, Department of Medical Science, Faculty of Science, Rangsit University, Pathum Thani, Thailand; [email protected]. · pubmed

Paper

Abstract

Age-related cerebral microvascular loss is associated with reduced angiogenesis and leads to inadequate tissue perfusion in the brain. Vascular endothelial growth factor (VEGF), crucial for angiogenesis, declines with age. Exercise enhances microvascular density and blood flow, promoting brain health. The specific mechanisms underlying exercise-induced angiogenesis in aging brains remain unclear. This study investigated the impact of exercise on microvessel density, tissue perfusion, and VEGF-angiogenic signaling in aging brains.

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Research summary

Exercise training enhances microvessel density and VEGF signaling in aging brains. This study addresses mechanisms that could mitigate age-related decline in cerebral microvascular health, contributing to the understanding of interventions that may promote longevity and brain health.

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