NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation.

Chenyang Yuan, Chen Feng, Tianyu Ma, Shufen Li, Mengting Liu, Gongrui Tang, Lu Han, Yazhi Xing, Tianhong Zhang

Department of Otolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital Affiliated to Harbin Medical University, Harbin, Heilongjiang, China; Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Rd, Shanghai, China.Department of Otolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital Affiliated to Harbin Medical University, Harbin, Heilongjiang, China; Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Rd, Shanghai, China. · pubmed

Paper

Abstract

Age-related hearing loss (ARHL) is a prevalent sensory disorder with significant clinical and social burdens, yet no FDA-approved pharmacological treatments are currently available. Emerging evidence implicates declined cellular NAD

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Research summary

NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation. This paper addresses a specific mechanism related to age-related hearing loss, which is a consequence of aging, and proposes a potential therapeutic approach that targets underlying cellular processes associated with aging.

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