Physical activity-associated extracellular vesicles inhibit inflammagen-induced microglial activation.
Abstract
Excessive microglial activation and neuroinflammation are pivotal contributors to the progression of neurodegenerative diseases. Physical activity has emerged as a complementary therapy recognized for its anti-inflammatory effects. Long-term treadmill-induced mandatory physical activity (TMPA), a rodent paradigm modeling exercise with controllable intensity, has been shown to reduce age-related microglial activation, dopaminergic neuron degeneration in the substantia nigra, and motor impairments in mice. However, the mechanisms underlying these effects remain unclear. Given the role of physical activity-induced exerkines in modulating anti-inflammatory responses, this study investigated the effects of plasma-derived extracellular vesicles (EVs) from TMPA-treated animals on inflammagen-induced microglial activation in both
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Research summary
The paper claims that plasma-derived extracellular vesicles from physically active animals can inhibit microglial activation induced by inflammation. This research is relevant as it explores mechanisms by which physical activity may mitigate neuroinflammation, a key factor in age-related neurodegenerative diseases, potentially addressing underlying causes of aging-related decline.
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