Magnetic resonance spectroscopy as a non-invasive tool for assessing brain and muscle adaptation to exercise training in older age: a scoping review into existing research.

Oron Levin, Ivica Just, Radka Klepochova, Shannon Helsper, Wouter Vints, Ana Filipa Silva, Antoine Langeard, Salit Bar Shalom, Christina Karatzaferi, Maryam Ziaei, Michel Audiffren, Claudia Voelcker-Rehage, Yael Netz, Nerijus Masiulis, Uwe Himmelreich, Martin Krššák

Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, LT-44221, Lithuania; Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, LT-44221, Lithuania; Biomedical MRI Unit, Department of Imaging and Pathology, Group Biomedical Sciences, KU Leuven, Leuven, 3000, Belgium; Frailty & Resilience in Ageing (FRIA) research department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, 1090, Belgium.Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, LT-44221, Lithuania; Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, LT-44221, Lithuania; Biomedical MRI Unit, Department of Imaging and Pathology, Group Biomedical Sciences, KU Leuven, Leuven, 3000, Belgium; Frailty & Resilience in Ageing (FRIA) research department, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, 1090, Belgium. · pubmed

Paper

Abstract

Exercise training has attracted increasing attention as a non-pharmacological intervention approach to counteract age-related deterioration of brain and muscle function, yet objective biomarkers are needed to understand mechanisms and optimize interventions. Magnetic resonance spectroscopy (MRS) provides non-invasive, in vivo assessment of metabolic profiles altered by aging and exercise. However, MRS-based exercise research in older populations remains limited. This scoping review aims to identify brain and muscle metabolites detectable by MRS that can serve as markers of exercise training effects in aging.

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Research summary

Magnetic resonance spectroscopy can identify brain and muscle metabolites that serve as markers for exercise training effects in aging. This paper addresses the need for objective biomarkers to understand and optimize non-pharmacological interventions aimed at counteracting age-related deterioration, which is central to longevity research.

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