Rosa chinensis cv. 'JinBian' flowers alleviates brain damage and cognitive deficit by inhibiting ferroptosis via the Keap1/Nrf2/GPX4 pathway and regulating gut microbiota.

Li Zhen, Jianhong Peng, Huimin Cui, Junhong Tao, Yaping Liu, Jianxin Cao, Hesham R El-Seedi, Guiguang Cheng, Zhengxuan Wang

Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, China; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China; Yunnan Key Laboratory of Plateau Food Advanced Manufacturing, Kunming 650500, China. · pubmed

Paper

Abstract

The flowers of Rosa chinensis cv. 'JinBian' (RCF) has been utilized as a herbal tea for millennia to prevent aging-related diseases. RCF is enriched in flavonoids and exhibits significant antioxidant effects for anti-aging potential. However, the specific bioactive compounds and their underlying anti-aging mechanisms remain unclear.

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Research summary

The paper claims that Rosa chinensis cv. 'JinBian' flowers can alleviate brain damage and cognitive deficits by inhibiting ferroptosis through the Keap1/Nrf2/GPX4 pathway and regulating gut microbiota. The research addresses mechanisms that may contribute to aging-related cognitive decline, which is relevant to longevity.

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