P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.

Yixin Zhou, Xin Zhong, Zhijie Mao, Yunxuan Chen, Jincheng Xing, Jiaxu Shen, Wenli Zhang, Ji Zhang, Jiaxuan Mei, Zhentong Yang, Zhuoqun Wang, Bozhi Ye, Jiahui Lin, Yonghua Wang, Zhouqing Huang

Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, The Key Laboratory of Cardiovascular Disease of Wenzhou, Wenzhou, China.Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, The Key Laboratory of Cardiovascular Disease of Wenzhou, Wenzhou, China. · pubmed

Paper

Abstract

Ageing is a significant risk factor for pathophysiological alterations in the heart, but the intrinsic mechanisms by which these occur have yet to be fully elucidated. Purinergic 2×7 receptor (P2X7R) is important for the pathogenesis of numerous cardiovascular diseases; nevertheless, its function in the process of cardiac ageing remains uncertain.

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Research summary

P2X7R deficiency enhances mitophagy and alleviates cardiac senescence through the HuR/TRIM26/NR4A1 axis. This research addresses mechanisms of cardiac aging, which is directly related to the fundamental processes of aging and age-related diseases.

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