Sestrin2 inhibits ferroptosis to alleviate hypertension via AMPK/Nrf2/GPX4 axis activation.

Yuan Li, Ju Yan, Fengchao Wu, Yongyong Zhao, Jie Qi, Zhenyu Wang, Yaozhang Guo, Haoyu Wu

Department of Cardiology, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Xi'an, 710068, Shaanxi Province, China.Department of Cardiology, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Xi'an, 710068, Shaanxi Province, China. · pubmed

Paper

Abstract

Despite advances in antihypertensive therapies, uncontrolled hypertension remains a major global health challenge, particularly among older adults. Ferroptosis, an iron-dependent programmed cell death, has been implicated in age-related vascular dysfunction, but its regulatory mechanisms in hypertension are unclear. This study investigates Sestrin2, a highly conserved stress-induced protein linked to cellular senescence, in regulating ferroptosis in hypertension.

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Research summary

Sestrin2 inhibits ferroptosis to alleviate hypertension via AMPK/Nrf2/GPX4 axis activation. This research addresses a mechanism related to cellular senescence and programmed cell death, which are critical factors in the aging process and age-related diseases.

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