Multi night digital assessment of sleep disordered breathing is associated with accelerated vascular aging.

Lucía Pinilla, Kelly Sansom, Philomène Letzelter, Andrew Vakulin, Ashley Montero, Anna Hudson, Pierre Escourrou, Jean-Louis Pepin, Robert Adams, Peter Catcheside, Bastien Lechat, Danny J Eckert

Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute: Sleep Health, Adelaide, SA, Australia. [email protected] University, College of Medicine and Public Health, Flinders Health and Medical Research Institute: Sleep Health, Adelaide, SA, Australia. [email protected]. · pubmed

Paper

Abstract

Pulse wave velocity (PWV) is a marker of vascular aging and cardiovascular risk. Obstructive sleep apnea (OSA) may accelerate vascular decline, but evidence from single-night assessments is inconsistent. We examined associations of multi-night OSA severity, night-to-night variability, and snoring with arterial stiffness in a real-world setting. Adults used two in-home digital devices over a ~ 4 y period: an under-mattress sleep sensor to quantify nightly OSA severity and snoring, and a smart scale to measure aortic-leg PWV. Among 29,653 participants from 20 countries (52 ± 12 years; 84% male; BMI 27.3 ± 4.9 kg/m

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Research summary

Multi-night assessments of obstructive sleep apnea severity are associated with increased arterial stiffness, indicating a potential link to accelerated vascular aging. The study addresses the relationship between sleep disordered breathing and vascular aging, which are critical factors in understanding and potentially mitigating age-related decline.

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