Geroprotective effect of Apigenin against skin senescence induced by an acute dose of gamma rays in male rats is associated with p-AMPK mediated autophagic flux.

Mahmoud E Habieb, Maha M Ali, Thanaa M Fahim, Fatma Y Abdou

Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. · pubmed

Paper

Abstract

One common side effect of radiotherapy is radiation-induced skin senescence. The current study is designed to explore the possible geroprotective effect of Apigenin (Api) against skin senescence induced by an acute dose of gamma rays in male rats. Thirty-two adult male rats were assigned into four groups: Control, γ-Radiation (6 Gy), Apigenin (50 mg/kg, orally), and Rad (6 Gy) + Api (50 mg/kg) for two weeks. Exposure to an acute dose of gamma radiation caused a significant increase in the levels of MDA and a significant decrease in GSH levels in comparison to control rats. Exposure to gamma radiation significantly increased skin collagen-1, p16

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Research summary

The paper claims that Apigenin has a geroprotective effect against skin senescence induced by gamma radiation in male rats through p-AMPK mediated autophagic flux. This research addresses a potential intervention for a specific aspect of aging-related damage, which aligns with the goal of understanding and mitigating the root causes of aging.

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