Ginkgetin alleviates UV-induced skin photoaging by reducing oxidative stress and promoting DNA repair via AKT-mediated homologous recombination repair.

Yiting Zhao, Liyuan Zhou, Shuzhan Shen, Xidie Yin, Qihang Chang, Yu Yan, Chunying Li, Zhi Cao, Haiyan Zhang, Qingyu Zeng, Xiuli Wang, Peiru Wang

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. · pubmed

Paper

Abstract

Ultraviolet (UV)-induced reactive oxygen species (ROS) production, DNA damage, and chronic inflammation lead to skin aging and cancers. Ginkgetin (GK), a biflavonoid derived from Ginkgo biloba, has known anti-inflammatory and antioxidant activities, but its anti-photoaging effect remains unclear.

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Research summary

Ginkgetin reduces oxidative stress and promotes DNA repair to alleviate UV-induced skin photoaging. The paper addresses mechanisms related to oxidative stress and DNA repair, which are fundamental processes in aging and longevity.

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