An age-associated decline in the role of the sarcoplasmic reticulum and associated calcium-handling proteins sets the pace for sinoatrial node function.

Sandra A Jones, Fiona S Godbeer, Matthew K Lancaster

Centre for Biomedicine, Hull York Medical School, Faculty of Health Sciences, University of Hull, Kingston-upon-Hull, UK.Centre for Biomedicine, Hull York Medical School, Faculty of Health Sciences, University of Hull, Kingston-upon-Hull, UK. · pubmed

Paper

Abstract

With advancing age, the intrinsic function of the sinoatrial node (SAN) declines, as a result of structural changes and changes in electrical regulation within the constitutive cells of the nodal tissue. This study examined changes to proteins involved in regulating calcium flux balance in the atria and SAN of male rats used as a model of ageing throughout their lifespan at 6, 12 and 24 months of age. Using immunohistochemistry and western blotting, we determined a significant age-dependent decline in the levels of key calcium regulatory proteins within the SAN: Ca

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Research summary

The paper claims that age-associated declines in calcium-handling proteins in the sinoatrial node contribute to its functional decline. This research is relevant as it addresses underlying mechanisms of aging that affect cardiac function, which is crucial for understanding age-related health decline.

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