Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study.

Lijie Kong, Chun Dou, Chaojie Ye, Dong Liu, Mingling Chen, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Ruixin Liu, Tiange Wang

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China. · pubmed

Paper

Abstract

Birthweight readily measurable marker of fetal growth that may influence health across the lifespan. We aimed to investigate the potential causal association between birthweight and healthy aging and to identify the mediating roles of subsequent socioeconomic, behavioral, functional, and disease-related factors to inform life-course strategies to promote healthy aging and reduce health inequities.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that birthweight has a causal association with healthy aging, mediated by various factors. This research is relevant as it explores the long-term influences of early life factors on aging, potentially informing strategies to promote healthier aging and address health disparities.

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