Deficiency of Werner RecQ-type DNA helicase causes premature malnutrition in zebrafish.

Kota Ujibe, Makoto Kashima, Miku Kataoka, Rintaro Shimada, Masashige Okamoto, Isao Kobayashi, Seiji Wada, Hiroki Matsuda, Akira Sakamoto, Hiromi Hirata

Laboratory of Brain Science, Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Kanagawa, Japan.Laboratory of Brain Science, Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Kanagawa, Japan. · pubmed

Paper

Abstract

Werner syndrome is a genetic progeria characterized by premature aging symptoms, but its early-onset pathology remains unclear. We generated

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Research summary

The paper claims that deficiency of Werner RecQ-type DNA helicase leads to premature malnutrition in zebrafish. This research is relevant as it explores the underlying mechanisms of a genetic progeria, potentially shedding light on aging processes and their root causes.

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