IL-2 silencing enables Tfh cell expansion during vaccination but is redundant for antibody production.
Abstract
Vaccines stimulate protective humoral immunity by coordinating lymphocyte activity in the germinal center (GC) response. However, the degree of protection varies across the population, with older individuals often showing lower titer antibody responses to vaccines. Previous work has correlated increased exposure to Th1 cytokines, like IL-2, with poor antibody responses in aging. Whether this is a causal relationship is unknown. Here we used Il2
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Research summary
IL-2 silencing enhances Tfh cell expansion during vaccination without affecting antibody production. This research addresses the immune response in aging, which is crucial for understanding and potentially mitigating age-related declines in vaccine efficacy.
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