A High Dose of Short-term Intraperitoneal D-galactose-induced Aging Process in Male Rats.

Ronald Winardi Kartika, Veronika Maria Sidharta, Tena Djuartina, Cynthia Retna Sartika, Kris Hemawan Timotius

Department of Surgery, Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Indonesia. · pubmed

Paper

Abstract

Intraperitoneal injection of D-galactose (D-gal i.p.) can accelerate aging has been used to develop models of aging previously, long-term use of D-gal has been used to induce aging in mice. Researchers are trying to determine whether short-term administration of high doses of D-gal i.p. in rats is able to induce significant signs similar to natural aging, namely increased oxidative stress and myostatin.

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Research summary

Short-term high doses of D-galactose can induce aging-like symptoms in male rats. This research explores mechanisms of aging, which is directly relevant to understanding and potentially addressing the root causes of aging.

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