Circulating endotrophin reflects inflammaging and mortality risk in older adults.

Clara F G Laursen, Federica Genovese, Morten Baltzer Houlind, Aino Leegaard Andersen, Morten Karsdal, Line J H Rasmussen, Juliette Tavenier

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. [email protected]. · pubmed

Paper

Abstract

Although interest in biomarkers of biological aging is growing, consensus on reliable, non-invasive indicators remains limited. Endotrophin, a bioactive fragment released during collagen type VI formation, reflects fibroblast activation and extracellular matrix remodeling and has been linked to chronic diseases, metabolic dysfunction, and inflammation. Whether circulating endotrophin also captures aging-related phenotypes and mortality risk in older adults remains unclear. We quantified serum endotrophin by the PRO-C6 assay in 1) acutely hospitalized Older patients (n = 121) at admission (T

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Research summary

Circulating endotrophin is associated with inflammaging and mortality risk in older adults. The study investigates a potential biomarker related to biological aging, which aligns with the exploration of aging mechanisms and their implications for longevity.

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