Fisetin-Mediated Topical Modulation of Senescent Cells in Skin Improves Wound Healing Dynamics in Diabetic Mice.

Asfia Numani, Margarita Carrasco-Jeldres, Barbara Hernandez-Rovira, K-Raman Purushothaman, Matthew M Melin, James L Kirkland, Saranya Wyles

Mayo Clinic Alix School of Medicine, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota.Mayo Clinic Alix School of Medicine, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota. · pubmed

Paper

Abstract

Diabetes mellitus affects over 25% of adults aged 65+ in the United States and is associated with a heightened risk of developing diabetic foot ulcers. Accumulation of senescent cells within the wound microenvironment can impair cutaneous repair, and senolytic therapies offer a promising approach to accelerate wound healing.

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Research summary

Fisetin treatment improves wound healing dynamics in diabetic mice by targeting senescent cells. The paper addresses the accumulation of senescent cells, which is a key factor in the aging process and age-related diseases, thus contributing to the understanding of potential interventions for longevity.

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