Corylin promotes longevity in Caenorhabditis elegans through DAF-16 and SKN-1 coordinated activation of autophagy-mitochondrial homeostasis axis.

Fu-Yi Shi, Chun Li, Xi-Yang Zhang, Li-Lan Ou, Gui-Sheng Wu, Huai-Rong Luo

Key Laboratory of Luzhou City for Aging Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. Electronic address: [email protected] Laboratory of Luzhou City for Aging Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Corylin is a natural flavonoid isolated from the seeds of Psoralea corylifolia L., a traditional medicinal herb historically used to treat bone-related disorders such as osteoporosis. However, its role in organismal aging and the underlying molecular mechanisms remain largely unexplored.

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Research summary

Corylin promotes longevity in C. elegans through the activation of autophagy and mitochondrial homeostasis via DAF-16 and SKN-1. The study explores a natural compound's potential to influence aging mechanisms, which aligns with the goal of understanding and potentially mitigating the root causes of aging.

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