Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging.

Namki Hong, Sang Wouk Cho, Alan A Cohen, Russell T Hepple, Paul M Coen, Bumsoo Ahn, Anne B Newman, Stephen B Kritchesky, Paul J Laurenti, Warren S Browner, Steven R Cummings

San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA. · pubmed

Paper

Abstract

Entropy may play an underappreciated role in human aging, such as in skeletal muscle functional declines. Histologically, muscle appears increasingly disorganized with aging, with greater fiber size variability and fiber-type grouping. We tested the hypothesis that entropy is associated with reduced physical performance and muscle function, independent of muscle mass. We quantified a homeostatic dysregulation index of muscle (HDI

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that entropy in muscle fiber histology is associated with reduced physical performance and muscle function in older adults. This research is relevant as it explores the relationship between muscle organization and functional decline in aging, addressing a potential underlying mechanism of age-related mobility issues.

Author of this paper? Send a correction.