Muscle-specific expression of Atg2 and high-fat diet influence age-related deterioration of skeletal muscle in aged drosophila via the ATGL/Sirt1/PGC-1α pathway.

Jingfeng Wang, Nijia Meng, Dengtai Wen

Ludong University, City Yantai, Shandong Province, 264025, China; Harbin Sport University, City Harbin, Heilongjiang Province, 150008, China.Ludong University, City Yantai, Shandong Province, 264025, China; Harbin Sport University, City Harbin, Heilongjiang Province, 150008, China. · pubmed

Paper

Abstract

Atg2 plays a vital role in regulating the ageing process. Autophagy and lysosomal repair depend on the lipid transport function of Atg2. The molecular mechanisms of the muscle Atg2 gene resistance to high-fat diet (HFD)-induced age-related damages of skeletal muscle are not known. In this study, we achieved overexpression and knockdown of the muscle Atg2 gene in drosophila by constructing the Atg2

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Research summary

The paper investigates the role of Atg2 in muscle deterioration due to aging and high-fat diet in Drosophila, suggesting that manipulating this gene could influence age-related muscle decline. This research addresses mechanisms underlying aging processes, which is pertinent to longevity studies.

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