Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing.

Guilherme H Souza Bomfim, Kesava Asam, Nish Patel, Anna Zou, Kristen Rosenberg, Erna Mitaishvili, Talita Aguiar, Emmanuel Zorn, Ravichandran Ramasamy, Bradley Aouizerat, Rodrigo S Lacruz

Department of Molecular Pathobiology, New York University College of Dentistry, NY, USA. · pubmed

Paper

Abstract

Ageing is the primary non-modifiable risk factor for cardiovascular diseases (CVDs), with older women facing a greater risk of CVDs than age-matched men. Vascular smooth muscle cells (VSMCs) dysfunction and impaired calcium (Ca

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Research summary

The paper claims that age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodeling and drives early vascular aging. This research addresses a mechanism underlying vascular aging, which is a critical aspect of longevity and age-related diseases.

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